Comparison of the oral and rectal mucosal and colonic serosal microcirculations of healthy, anesthetized horses

Kieffer, P. J.; Williams, J. M.; Shepard, M. K.; Giquere, S.; Epstein, K. L.

Comparison of the oral and rectal mucosal and colonic serosal microcirculations of healthy, anesthetized horses

2018

Kieffer, P. J. | Williams, J. M. | Shepard, M. K. | Giquere, S. | Epstein, K. L.

The objectives of the study were to: i) determine baseline microvascular perfusion indices (MPI) and assess their repeatability in healthy horses under general anesthesia, and ii) compare the MPIs of 3 microvascular beds (oral mucosa, colonic serosa, and rectal mucosa). Healthy adult horses were anesthetized and sidestream dark field microscopy was used to collect video loops of the oral mucosa, rectal mucosa, and colonic serosa under normotensive conditions without cardiovascular support drugs; videos were later analyzed to produce MPIs. Baseline MPI values were determined for each site, which included the total vessel density (TVD), perfused vessel density (PVD), portion perfused vessels (PPV), and microcirculatory flow index (MFI). Differences in MPIs between microvascular beds were not statistically significant. Repeatability of the measurements varied for each MPI. In particular, the site of sampling had a profound effect on the repeatability of the PPV measurements and should be considered in future studies.

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