Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor
2015
Kim, Jeonghyun | Montagne, Kevin | Ushida, Takashi | Furukawa, Katsuko
In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Furthermore, we showed that loading hydrostatic pressure induced the upregulation of PKR, which is known to participate in mechanotransduction in various models.
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