Short-term effects of atmospheric particulate matter on myocardial infarction: a cumulative meta-analysis

Cai, Xianlei; Li, Zhenhong; Scott, E Marian; Li, Xiuyang; Tang, Mengyao

Short-term effects of atmospheric particulate matter on myocardial infarction: a cumulative meta-analysis

2016

Cai, Xianlei | Li, Zhenhong | Scott, E Marian | Li, Xiuyang | Tang, Mengyao

Atmospheric particulate matter (PM) is hypothesized to increase the risk of myocardial infarction (MI). However, the epidemiological evidence is inconsistent. We identified 33 studies with more than 4 million MI patients and applied meta-analysis and meta-regression to assess the available evidence. Twenty-five studies presented the effects of the PM level on hospitalization for MI patients, while eight studies showed the effects on mortality. An increase in PM₁₀ was associated with hospitalization and mortality in myocardial infarction patients (RR per 10 μg/m³ = 1.011, 95 % CI 1.006–1.016; RR per 10 μg/m³ = 1.008, 95 % CI 1.004–1.012, respectively); PM₂.₅ also increased the risk of hospitalization and mortality in MI patients (RR per 10 μg/m³ = 1.024, 95 % CI 1.007–1.041 for hospitalization and RR per 10 μg/m³ = 1.012, 95 % CI 1.010–1.015 for mortality). The results of the cumulative meta-analysis indicated that PM₁₀ and PM₂.₅ were associated with myocardial infarctionwith the addition of new studies each year. In conclusion, short-term exposure to high PM₁₀ and PM₂.₅ levels revealed to increase risk of hospitalization and mortality for myocardial infarction. Policy support of pollution control and individual protection was strongly recommended.

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