Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease

Watanabe, Akiko; Ohata, Keiichi; Oikawa, Tsuyoshi; Sugaya, Takeshi; Miyazaki, Masao; Satoh, Hiroshi; Katayama, Masaaki

Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease

2021

Urinary liver-type fatty acid-binding protein (uL-FABP) is a clinically useful biomarker for monitoring chronic kidney disease (CKD) in humans. However, long-term monitoring of uL-FABP in CKD cats has not been reported. The objective of this preliminary study was to investigate whether the urinary excretion of L-FABP could predict the deterioration of renal function in 2 CKD model cats. Urinary liver-type fatty acid-binding protein (uL-FABP) increased before standard renal biomarkers, including serum creatinine, blood urea nitrogen, and symmetric dimethylarginine, in 1 cat with deteriorating renal function, but remained low and relatively stable in another cat with stable renal function. Our results suggest that uL-FABP is a potential clinical biomarker for predicting the progression of CKD in cats, as it is in humans.

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