Levels of circulating anti-muscarinic and anti-adrenergic antibodies and their effect on cardiac arrhythmias and dysautonomia in murine models of Chagas disease
2014
DALIRY, ANISSA | PEREIRA, ISABELA RESENDE | PEREIRA-JUNIOR, PEDRO PAULO | RAMOS, ISALIRA PEROBA | VILAR-PEREIRA, GLAUCIA | SILVARES, RAQUEL RANGEL | LANNES-VIEIRA, JOSELI | Carvalho, Antonio Carlos Campos de
Antibodies (Ab) recognizing G-protein coupled receptors, such as β ₁ and β ₂ adrenergic (anti-β ₁-AR and anti-β ₂-AR, respectively) and muscarinic cholinergic receptors (anti-M₂-CR) may contribute to cardiac damage, however their role in chronic chagasic cardiomyopathy is still controversial. We describe that Trypanosoma cruzi-infected C3H/He mice show increased P and QRS wave duration, and PR and QTc intervals, while the most significant ECG alterations in C57BL/6 are prolonged P wave and PR interval. Echocardiogram analyses show right ventricle dilation in infected animals of both mouse lineages. Analyses of heart rate variability (HRV) in chronically infected C3H/He mice show no alteration of the evaluated parameters, while C57BL/6 infected mice display significantly lower values of HRV components, suggesting autonomic dysfunction. The time-course analysis of anti-β ₁-AR, anti-β ₂-AR and anti-M₂-CR Ab titres in C3H/He infected mice indicate that anti-β ₁-AR Ab are detected only in the chronic phase, while anti-β ₂-AR and anti-M₂-CR are observed in the acute phase, diminish at 60 dpi and increase again in the chronic phase. Chronically infected C57BL/6 mice presented a significant increase in only anti-M₂-CR Ab titres. Furthermore, anti-β ₁-AR, anti-β ₂-AR and anti-M₂-CR, exhibit significantly higher prevalence in chronically T. cruzi-infected C3H/He mice when compared with C57BL/6. These observations suggest that T. cruzi infection leads to host-specific cardiac electric alterations.
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