Estimation of environmentally relevant chemical properties of veterinary ionophore antibiotics

Sun, Peizhe; Pavlostathis, Spyros G.; Huang, Ching-Hua

Estimation of environmentally relevant chemical properties of veterinary ionophore antibiotics

2016

Sun, Peizhe | Pavlostathis, Spyros G. | Huang, Ching-Hua

Monensin (MON) and salinomycin (SAL), known as polyether ionophore antibiotics (IPAs), are extensively used in livestock industry and can enter the environment via animal manure and agricultural runoff. Although some studies have investigated the environmental fate and transformation of IPAs, the lack of information on IPAs’ aqueous-phase chemical properties is a major hindrance for further in-depth research. This study was able to experimentally determine the acidity constants (pKa), metal-complex dissociation constants (Kdᵢₛₛ), and intrinsic aqueous solubility of MON species, and some of these properties of SAL. The pKₐ value of MON was found to be 4.5, close to other aliphatic carboxylic acids and the predicted value by the computer program ChemAxon. The metal-complex dissociation constants of MON were estimated to be 0.058 and 0.573 with sodium ion (Na⁺) and potassium ion (K⁺), respectively. The Kdᵢₛₛ value of SAL with sodium ion was found to be 1.31. Compared to the previous values determined in organic solvents, the Kdᵢₛₛ of MON in aqueous phase are several orders of magnitude higher but maintain the same relative selectivity toward metal ions (Na⁺ versus K⁺). The determined pKa and Kdᵢₛₛ values were also used to assess the aqueous solubility limits of different IPA species under different pH and metal ion concentrations. Results from this study provide more accurate information for the properties of IPAs. The obtained constants can be applied to predict the speciation of IPAs in various aquatic systems and help shed light on the environmental fate of IPAs.

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