Acylphloroglucinol Derivatives from Hypericum andinum: Antidepressant-like Activity of Andinin A

Ccana-Ccapatinta, Gari V.; Stolz, Eveline D.; da Costa, Paola F.; Rates, Stela M. K.; von Poser, Gilsane L.

Acylphloroglucinol Derivatives from Hypericum andinum: Antidepressant-like Activity of Andinin A

2014

Ccana-Ccapatinta, Gari V. | Stolz, Eveline D. | da Costa, Paola F. | Rates, Stela M. K. | von Poser, Gilsane L.

A new dimeric acylphloroglucinol derivative, andinin A (1), was isolated from the underground plant parts of Hypericum andinum, along with three known dimeric acylphloroglucinols, uliginosin A (2), uliginosin B (3), and isouliginosin B (4). The structure of 1 was elucidated using 1D and 2D NMR and MS experiments and by comparison with previously reported data for Hypericum dimeric acylphloroglucinols. Andinin A (1) displayed antidepressant-like activity in a mouse forced-swimming test when administered orally at doses of 3, 10, and 30 mg/kg.

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