A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997–1998 season in Tokyo

Mori, S.-I.; Nagashima, M.; Sasaki, Y.; Mori, K.; Tabei, Y.; Yoshida, Y.; Yamazaki, K.; Hirata, I.; Sekine, H.; Ito, T.; Suzuki, S.

A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997–1998 season in Tokyo

1999

We analyzed the hemagglutinin (HA) genes of influenza A viruses consisting of 6 strains isolated from cerebrospinal fluids of patients with encephalopathy and 3 isolates from throat washes of patients without central nervous system symptoms during the 1997–1998 season in Tokyo. Aligned 9 amino acid sequences showed 7 common substitutions compared with A/Wuhan/359/95 (vaccine strain used in the season in Japan), which were allocated to three different antigenic sites on the H3 HA molecule. It is noted that a novel substitution at the receptor-binding site (Tyr-137 to Phe) was found exclusively in the isolates from the patients with encephalopathy.

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Ключевые слова АГРОВОК

amino acid sequences binding sites brain diseases central nervous system encephalopathy genes genetics hemagglutinins humans infant orthomyxoviridae pathogenicity patients physiology physiopathology point mutation receptors virology virulence virus

Библиографическая информация

Опубликовано в

Archives of virology

Том 144 Выпуск 1 Нумерация страниц 147 - 155 ISSN 0304-8608

Издатель

Springer-Verlag

Другие темы

Influenza a virus; H3n2 subtype; Preschool; Child; Influenza virus; Hemagglutinin glycoproteins; Molecular sequence data; Female; Amino acid sequence; Male; Influenza a virus; Human; Influenza; Child; Amino acid substitution; Amino acid substitution

Язык

Английский

Тип

Text; Journal Article

В АГРИСе с: 2024-02-28

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

Откройте коллекцию этого поставщика данных в AGRIS

Ссылки

DOI http://dx.doi.org/10.1007/s007050050491

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