Cerebrospinal fluid analysis of rabid and vaccina-rabies glycoprotein recombinant, orally vaccinated raccoons (Procyon lotor)

Hanlon, C.A.; Ziemer, E.L.; Hamir, A.N.; Rupprecht, C.E.

Cerebrospinal fluid analysis of rabid and vaccina-rabies glycoprotein recombinant, orally vaccinated raccoons (Procyon lotor)

1989

Hanlon, C.A. | Ziemer, E.L. | Hamir, A.N. | Rupprecht, C.E.

Cerebrospinal fluid obtained from clinically normal free-ranging raccoons was analyzed and compared with CSF obtained from raccoons vaccinated orally with vaccinia-rabies glycoprotein (V-RG) recombinant virus vaccine and subsequently challenged peripherally with street rabies virus, and CSF from naive, rabies virus challenge-exposed control raccoons. Significant differences were not found in CSF of free-ranging or V-RG recombinant virus vaccine recipient raccoons, and there was no evidence of CNS invasion by V-RG virus. The CSF of naive, rabies challenge-exposed control raccoons contained high numbers of lymphocytes and monocytes, compatible with rabies virus encephalitis. Although V-RG orally vaccinated challenge-exposed raccoons were protected from lethal rabies virus infection, mild lymphocytic pleocytosis was evident at 90 days after challenge exposure.

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