Oxidative stress induced by nanoplastics in the liver of juvenile large yellow croaker Larimichthys crocea

Li, Li'ang; Gu, Huaxin; Chang, Xueqing; Huang, Wei; Sokolova, Inna M.; Wei, Shuaishuai; Sun, Li; Li, Shanglu; Wang, Xinghuo; Hu, Menghong; Zeng, Jiangning; Wang, Youji

Oxidative stress induced by nanoplastics in the liver of juvenile large yellow croaker Larimichthys crocea

2021

There are many toxicological studies on microplastics, but little is known about the effect of nanoplastics (NPs). Here, we evaluated the oxidative stress responses induced by NPs (10, 10⁴ and 10⁶ particles/l) in juvenile Larimichthys crocea during 14-d NPs exposure followed by a 7-d recovery. After exposure, the activities of antioxidant enzymes (SOD, CAT, GPx) and MDA levels increased in the liver of fish at the highest NPs concentration. SOD and CAT activities remained elevated above the baseline after recovery under high-concentration NPs but returned to the baseline in two other NP treatments. Although lipid peroxidation in liver was reversible, juvenile fish in NPs treatments exhibited a lower survival rate than the control during both exposure and recovery. Furthermore, IBR value and PCA analysis showed the potential adverse effects of NPs. Considering that NPs can reduce the survival of fish juveniles, impacts of NPs on fishery productivity should be considered.

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