Induction of Apoptosis in DLD-1 Human Colon Cancer Cells by Peridinin Isolated from the Dinoflagellate, Heterocapsa triquetra
SUGAWARA, Tatsuya | Yamashita, Kyōko | SAKAI, Shota | ASAI, Akira | NAGAO, Akihiko | SHIRAISHI, Tomotaka | IMAI, Ichiro | HIRATA, Takashi
Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0–20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.
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