Induction of Apoptosis in DLD-1 Human Colon Cancer Cells by Peridinin Isolated from the Dinoflagellate, Heterocapsa triquetra
2007
SUGAWARA, Tatsuya | Yamashita, Kyōko | SAKAI, Shota | ASAI, Akira | NAGAO, Akihiko | SHIRAISHI, Tomotaka | IMAI, Ichiro | HIRATA, Takashi
Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0–20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.
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书目信息
出版者
Japan Society for Bioscience, Biotechnology, and Agrochemistry
其它主题
Peridinin; Dose response; Heterocapsa; Caspase-9; Caspase-8; Colon cancer cells; Cell viability; Dinoflagellate; Colorectal neoplasms; Biobased products
语言
英语
注释
Nal-ap-2-clean
类型
Journal Article; Text
2024-02-28
2026-02-03
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