One-pot synthesis of polycyclic isoindolines using isoindole umpolung
2020
Weintraub, Rachel A. | He, Wei | Wang, Xiang
Using an isoindole umpolung strategy, a one-pot synthesis of polycyclic isoindolines was accomplished. In this reaction, the in situ-generated nucleophilic isoindoles were converted to electrophilic isoindoliums via protonation, which underwent a Pictet-Spengler-type cyclization to afford a variety of polycyclic isoindolines in good yields.
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Эту запись предоставил National Agricultural Library