One-pot synthesis of polycyclic isoindolines using isoindole umpolung
2020
Weintraub, Rachel A. | He, Wei | Wang, Xiang
Using an isoindole umpolung strategy, a one-pot synthesis of polycyclic isoindolines was accomplished. In this reaction, the in situ-generated nucleophilic isoindoles were converted to electrophilic isoindoliums via protonation, which underwent a Pictet-Spengler-type cyclization to afford a variety of polycyclic isoindolines in good yields.
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书目信息
出版者
Elsevier Ltd
其它主题
One-pot reaction; Isoindole; Lewis acids; Lewis bases; Umpolung; Cyclization; Protonation
语言
英语
注释
Nal-ap-2-clean
类型
Journal Article; Text
2024-02-28
MODS