The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

Zhai, Fengguang; Li, Jingyun; Ye, Meng; Jin, Xiaofeng

The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

2022

Zhai, Fengguang | Li, Jingyun | Ye, Meng | Jin, Xiaofeng

Ubiquitination of substrates usually have two fates: one is degraded by 26S proteasome, and the other is non-degradative ubiquitination modification which is associated with cell cycle regulation, chromosome inactivation, protein transportation, tumorigenesis, achondroplasia, and neurological diseases. Cullin3 (CUL3), a scaffold protein, binding with the Bric-a-Brac-Tramtrack-Broad-complex (BTB) domain of substrates recognition adaptor and RING-finger protein 1 (RBX1) form ubiquitin ligases (E3). Based on the current researches, this review has summarized the functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination.

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Ключевые слова АГРОВОК

ar carcinogenesis cell cycle chromosomes cns copii ddr genes irak lys mcm sac ser transportation

Библиографическая информация

Опубликовано в

Gene

Том 832 Нумерация страниц 146562 ISSN 0378-1119

Издатель

Elsevier B.V.

Другие темы

Crn7; Er; Incenp; Rme; Proteasome endopeptidase complex; Hd; Npcd; G1; Pcr1; Pca; Dht; Nsclc; Edr1/hph1; H3k9me3; Dd; Np1; Scaffolding proteins; Nhej; Hr; Ring; Tgn; Np2; Plk1; Pcr2; Ires; Myd88; Ubiquitin ligases; Aggresomes; Cul3kbtbd8; Uba; Xi; Pcg; Apc; Itafs; Ezh2; Suz12; Rbx; Ad; Tlr; Xist; Traf6; Prc; Ic3; Spop; Gpcr; E3; Cdt1; Shrna; Lc3; Pd; Rna pol i; Dgr; Hesc; Pbd; Ubiquitin-protein ligase; Skp2; Hipk2; Cblc; E2; M1; P62; Pb1; Pbip1; Culs; Orc; Tir; Sbc; Npc; Tkis; Ring finger domains; Dsbs; Inf2; Uim; Kt-mt; Vcp/p97; Caax; Klhl; H4k20me2; Tcof1; Ubiquitination; Cdc6; G2; Cpc; Cullin3; Αegfr; Srs; Nolc1; 53bp1; Adt; Nf-κb; Crpc; Crls; Nrf2; Eed; Mcb; Btb; 17βhsd4; Ecm; Non-degradative; Sec; Khsrp; Thr; Atm; Udr; Cdk1; Ctr; E1; Pre-rc; Npl4

Язык

Английский

Тип

Journal Article; Text

В АГРИСе с: 2024-02-28

Формат: MODS

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Эту запись предоставил National Agricultural Library

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Ссылки

DOI DOI https://dx.doi.org/10.1016/j.gene.2022.146562

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ФАО АГРИС — международная информационная система по сельскохозяйственным наукам и технологиям

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The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

2022

Ключевые слова АГРОВОК

Библиографическая информация