The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

Zhai, Fengguang; Li, Jingyun; Ye, Meng; Jin, Xiaofeng

The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

2022

Zhai, Fengguang | Li, Jingyun | Ye, Meng | Jin, Xiaofeng

Ubiquitination of substrates usually have two fates: one is degraded by 26S proteasome, and the other is non-degradative ubiquitination modification which is associated with cell cycle regulation, chromosome inactivation, protein transportation, tumorigenesis, achondroplasia, and neurological diseases. Cullin3 (CUL3), a scaffold protein, binding with the Bric-a-Brac-Tramtrack-Broad-complex (BTB) domain of substrates recognition adaptor and RING-finger protein 1 (RBX1) form ubiquitin ligases (E3). Based on the current researches, this review has summarized the functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination.

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AGROVOC关键词

ar carcinogenesis cell cycle chromosomes cns copii ddr genes irak lys mcm sac ser transportation

书目信息

发表于

Gene

卷 832 页码 146562 ISSN 0378-1119

出版者

Elsevier B.V.

其它主题

Cdk1; Shrna; Npl4; Scaffolding proteins; Tcof1; E3; Mcb; Crn7; Sbc; Apc; Nsclc; Btb; Ubiquitin-protein ligase; Cpc; Ring; Crpc; Hd; Nhej; Culs; Ezh2; Proteasome endopeptidase complex; Nolc1; Vcp/p97; Rme; Αegfr; P62; Klhl; Uba; Dsbs; 17βhsd4; Atm; Spop; E1; Pcg; Npcd; Ires; Pbd; Hipk2; Tir; Uim; Pbip1; Hesc; Ubiquitin ligases; Orc; Kt-mt; Er; Cdt1; Pcr1; Skp2; Tlr; Pcr2; Cdc6; Incenp; Dd; Dgr; Xi; Tgn; Lc3; Plk1; Itafs; Xist; Ubiquitination; Hr; G2; H3k9me3; Pca; Dht; Inf2; Ecm; Ring finger domains; Np2; E2; Nf-κb; Pre-rc; Gpcr; Prc; Thr; Suz12; 53bp1; Myd88; Rna pol i; Ctr; Edr1/hph1; G1; Sec; Npc; Cullin3; Khsrp; M1; Tkis; Pd; Non-degradative; Aggresomes; H4k20me2; Ic3; Traf6; Np1; Cblc; Rbx; Srs; Adt; Udr; Pb1; Cul3kbtbd8; Ad; Nrf2; Crls; Eed; Caax

语言

英语

类型

Journal Article; Text

自何时收录于AGRIS: 2024-02-28

格式: MODS

数据提供者

这条记录提供自 National Agricultural Library

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链接

DOI DOI https://dx.doi.org/10.1016/j.gene.2022.146562

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