Urinary excretion of arsenic following rice consumption

Meharg, A.A.; Williams, P.N.; Deacon, C.M.; Norton, G.J.; Hossain, M.; Louhing, D.; Marwa, E.; Lawgalwi, Y.; Taggart, M.; Cascio, C.; Haris, P.

Urinary excretion of arsenic following rice consumption

2014

Patterns of arsenic excretion were followed in a cohort (n = 6) eating a defined rice diet, 300 g per day d.wt. where arsenic speciation was characterized in cooked rice, following a period of abstinence from rice, and other high arsenic containing foods. A control group who did not consume rice were also monitored. The rice consumed in the study contained inorganic arsenic and dimethylarsinic acid (DMA) at a ratio of 1:1, yet the urine speciation was dominated by DMA (90%). At steady state (rice consumption/urinary excretion) ∼40% of rice derived arsenic was excreted via urine. By monitoring of each urine pass throughout the day it was observed that there was considerable variation (up to 13-fold) for an individual's total arsenic urine content, and that there was a time dependent variation in urinary total arsenic content. This calls into question the robustness of routinely used first pass/spot check urine sampling for arsenic analysis.

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