Inhibition of cAMP Phosphodiesterase by Some Phototherapeutic Agents
2014
Bovalini, Lucia | Lusini, Paola | Simoni, Sandra | Vedaldi, Daniela | Andreassi, Lucio | Dall’Acqua, Francesco | Martelli, Paola
The behaviour of cyclic-3′,5′-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) (usu ally used in PUVA therapy), 4.6,4′-trimethylangelicin (TMA) and khellin recently proposed for the same thera peutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration.
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