Vitamin A transporting plasma proteins and female sex hormones

Vahlguist, Anders; Johnsson, Anita; Nygren, Karl-Gosta

Vitamin A transporting plasma proteins and female sex hormones

1979

Vahlguist, Anders | Johnsson, Anita | Nygren, Karl-Gosta

Retinol-binding protein, prealbumin, and sex steroid plasma levels were estimated daily in four women during the course of a normal menstrual cycle and in three women during treatment with combined oral contraceptives. The retinol-binding protein level showed a bicyclic variation during the menstrual cycle. No consistent pattern of variation for prealbumin was observed. Oral contraceptives induced a significant increase of retinol-binding protein which correlated with the increase of vitamin A. The increase was about 35% for the formulation containing synthetic estrogen as compared with 15% for the natural estrogen formulation. In relation to retinol-binding protein, the plasma level of prealbumin showed a less rapid increase but the final increment after oral contraceptive therapy appeared to be of the same magnitude for both proteins.

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