2-methoxy-isobutyl-isonitrile-conjugated gold nanoparticles improves redox and inflammatory profile in infarcted rats
2020
Tartuce, Ludimilla Pereira | Pacheco Brandt, Fábio | dos Santos Pedroso, Giulia | Rezende Farias, Hemelin | Barros Fernandes, Bruna | da Costa Pereira, Bárbara | Gonçalves Machado, Alessandra | Feuser, Paulo Emílio | Lock Silveira, Paulo Cesar | Tiscoski Nesi, Renata | da Silva Paula, Marcos Marques | Andrades, Michael | de Pinho, Ricardo Aurino
The tissue response to acute myocardial infarction (AMI) is key to avoiding heart complications due to inflammation, mitochondrial dysfunction, and oxidative stress. Antioxidant and anti-inflammatory agents can minimize the effects of AMI. This study investigated the role of 2-methoxy-isobutyl-isonitrile (MIBI)-associated gold nanoparticles (AuNP) on reperfusion injury after ischemia and its effect on cardiac remodeling in an experimental AMI model. Three-month-old Wistar rats were subjected to a temporary blockade of the anterior descending artery for 30 min followed by reperfusion after 24 h and 7 days by intraventricularly administering 0.4, 1.3, and 3 mg/kg AuNP-MIBI. The cardiac toxicity and renal and hepatic function levels were determined, and the infarct and peri-infarct regions were surgically removed for histopathology, analysis of inflammation from oxidative stress, and echocardiography. MIBI-conjugated AuNP promoted changes in oxidative stress and inflammation depending on the concentrations used, suggesting promising applicability for therapeutic purposes.
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