Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia
2011
Kapche, Gilbert D.W.F. | Amadou, Dawe | Waffo-Teguo, Pierre | Donfack, Jean H. | Fozing, Christian D. | Harakat, Dominique | Tchana, Angele N. | Merillon, Jean M. | Moundipa, Paul F. | Ngadjui, Bonaventure T. | Abegaz, Berhanu M.
The chemical investigation of the twigs of Morus mesozygia resulted in the isolation of three new prenylated 2-arylbenzofurans, named moracin KM, LM, and SC (1-3), nine known 2-arylbenzofurans (4-12), and two known flavonoids (13-14). The structures of the new compounds were established as [2′′,3′′:6,7]-(6-(S)-hydroxymethyl-6-methylpyrano)-2-(3,5-dihydroxyphenyl)benzofuran-5-ol (1), [2′′,3′′:6,7]- (4,7-dihydro-6-methyloxepine)-2-(3-hydroxy-5-methoxyphenyl)benzofuran-5-ol (2), and [2′′,3′′:6,7]-(6,6-dimethylpyrano)-2-(3,5-dihydroxyphenyl)benzofuran (3). One of the new compounds, moracin LM (2), displayed modest antioxidant activity, whereas known compounds 4, 13, and 14 showed significant hepatoprotective and antioxidant activities.
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