The effect of nitrous oxide on the minimum alveolar concentration (MAC) and MAC derivatives of isoflurane in dogs
2013
Voulgaris, Debra A. | Egger, Christine M. | Seddighi, M Reza | Rohrbach, Barton W. | Love, Lydia C. | Doherty, Thomas J.
This study investigated the effects of 70% nitrous oxide (N(2)O) on the minimum alveolar concentration (MAC) of isoflurane (ISO) that prevents purposeful movement, the MAC of ISO at which there is no motor movement (MAC(NM)), and the MAC of ISO at which autonomic responses are blocked (MAC(BAR)) in dogs. Six adult, healthy, mixed-breed, intact male dogs were anesthetized with ISO delivered via mask. Baseline MAC, MAC(NM), and MACBAR of ISO were determined for each dog using a supra-maximal electrical stimulus (50 V, 50 Hz, 10 ms). Nitrous oxide (70%) was then administered and MAC and its derivatives (N(2)O-MAC, N(2)O-MAC(NM), and N(2)O-MAC(BAR)) were determined using the same methodology. The values for baseline MAC, MAC(NM), and MAC(BAR) were 1.39 ± 0.14, 1.59 ± 0.10, and 1.72 ± 0.16, respectively. The addition of 70% N(2)O decreased MAC, MAC(NM), and MAC(BAR) by 32%, 15%, and 25%, respectively.
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