Examination of the effect of agitation on the potency of the Ebola Zaire vaccine rVSVΔG-ZEBOV-GP

Davis, Harrison; Dow, Tylina; Isopi, Lynne; Blue, Jeffrey T.

Examination of the effect of agitation on the potency of the Ebola Zaire vaccine rVSVΔG-ZEBOV-GP

2020

Davis, Harrison | Dow, Tylina | Isopi, Lynne | Blue, Jeffrey T.

The Ebolavirus vaccine (rVSVΔG-ZEBOV-GP) is stored at −80 to −60 °C and should be kept frozen for transport. Due to significant logistical challenges, frozen transport is not feasible for some remote locations. To determine if local distribution at 2–8 °C is a potential option for these locations, a study was conducted to evaluate the impact of agitation on the thawed vaccine. After up to 7 days of constant agitation, no impact on vaccine potency was evident for the agitated vaccine versus the corresponding vaccine kept stationary at 2–8 °C. In conclusion, in-country transport of the Ebolavirus vaccine, rVSVΔG-ZEBOV-GP, at 2–8 °C appears to be a feasible option for those remote locations where significant logistical challenges prohibit transporting the vaccine at −80 to −60 °C.

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