Deferiprone: structural and functional modulating agent of hemoglobin fructation

Sattarahmady, Naghmeh; Heli, Hossein; Moosavi-Movahedi, Ali A.; Karimian, K.

Deferiprone: structural and functional modulating agent of hemoglobin fructation

2014

Sattarahmady, Naghmeh | Heli, Hossein | Moosavi-Movahedi, Ali A. | Karimian, K.

Diabetic complication arises from the presence of advanced glycation end products in different sites of the body. Great attention should be paid to recognizing anti-glycation compounds. Here, deferiprone as an oral iron chelator drug administrated in treatment of β-thalassemic patients was selected to find its effect on the fructation of hemoglobin (Hb). Our results indicated that deferiprone could prevent the AGE and carbonyl formation via inhibition of structural changes in the structure of Hb during the fructation process. Moreover, deferiprone can preserve peroxidase and esterase activities of fructated Hb similar to native Hb. Therefore, deferiprone can be introduced as an anti-glycation drug to prevent the AGE formation.

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