Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs

Ward, D.A.; Ferguson, D.C.; Kaswan, R.L.; Green, K.; Bellhorn, R.W.

Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs

1991

Ward, D.A. | Ferguson, D.C. | Kaswan, R.L. | Green, K. | Bellhorn, R.W.

A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disruption induced by a slow, controlled paracentesis of a small volume of aqueous humor may provide the most reliable model for drug testing. Additionally, fluorophotometry proved to be a sensitive and accurate means of detecting breakdown of the blood-aqueous barrier.

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