Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8⁺ T-cells promotes their mechanotransduction and activation
2021
Li, Rui | Ali, Walida | Ma, Chao | Bajpai, Apratim | Luu, Ngoc | Varshney, Aarushi | Rowe, Camden Riley | Chen, Weiqiang
We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8⁺ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.
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