Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review)
2010
Iradyan, M. A | Iradyan, N. S | Stepanyan, G. M | Arsenyan, F. G | Garibdzhanyan, B. T
The physicochemical properties and antitumor activity of dacarbazine, its analogs, and the new alkylating agent imidazene are reviewed. It is shown that the activity of dacarbazine is superior to most of its analogs. Imidazene exhibits an advantage over dacarbazine with respect to both stability and activity and can be used for the treatment of malignant melanoma and sarcoma of soft tissues and in combined chemotherapy.
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