Ozonation of metoprolol in aqueous solution: ozonation by-products and mechanisms of degradation

Tay, Kheng Soo; Rahman, Noorsaadah Abd; Abas, Mhd Radzi Bin

Ozonation of metoprolol in aqueous solution: ozonation by-products and mechanisms of degradation

2013

Tay, Kheng Soo | Rahman, Noorsaadah Abd | Abas, Mhd Radzi Bin

This study investigated the degradation pathway of metoprolol, a widely used β-blocker, in the ozonation via the identification of generated ozonation by-products (OPs). Structure elucidation of OPs was performed using HPLC coupled with quadrupole time-of-flight high-resolution mass spectrometry. Seven OPs were identified, and four of these have not been reported elsewhere. Identified OPs of metoprolol included aromatic ring breakdown by-products; aliphatic chain degraded by-products and aromatic ring mono-, di-, and tetrahydroxylated derivatives. Based on the detected OPs, metoprolol could be degraded through aromatic ring opening reaction via reaction with ozone (O₃) and degradation of aliphatic chain and aromatic ring via reaction with hydroxyl radical (•OH).

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