Urethral pressure response to alpha-adrenergic agonists and antagonist drugs in anesthetized healthy male cats

Frenier, S.L.; Knowlen, G.G.; Speth, R.C.; Moore, M.P.

Urethral pressure response to alpha-adrenergic agonists and antagonist drugs in anesthetized healthy male cats

1992

Frenier, S.L. | Knowlen, G.G. | Speth, R.C. | Moore, M.P.

Urethral smooth muscle tone in response to treatment with phenylephrine, a selective alpha 1-adrenergic receptor agonist, and prazosin a selective alpha 1-adrenergic receptor antagonist, was evaluated in 12 anesthetized healthy adult sexually intact male cats. Intravenous administration of prazosin (20 to 30 micrograms/kg of body weight) decreased the average preprostatic and prostatic intraurethral pressure, compared with baseline and postphenylephrine (20 to 30 micrograms(kg) administration, values. Neither prazosin nor phenylephrine administration had an effect on functional urethral length. Results have implications for the pharmacologic management of lower urinary tract disorders in male cats.

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