THE PROTECTIVE POTENCY OF GREEN TEA AND GINGER EXTRACTS ON THE GENOTOXIC EFFECT OF MALATHION INSECTICIDE IN BONE MARROW CELLS OF MICE (MUS MUSCULUS)
2005
Hashim Ekram F. | Abdella Ehab M.
In present set of investigations the chemoprotective effect of green tea and ginger extracts has been evaluated using in vivo chromosomal aberrations assay in albino mice (Mus musculus). The organophosphate agropesticide malathion, 80% technical grade consider as a potent genotoxic agent, was given at a single dose 230 mg/kg b.w. (1/12 LD50) intraperitoneally. Pretreatment with 4 and 3% of freshly prepared green tea (GTI), ginger (GI) extracts, respectively and the mixture of both extracts (GTI+GI) were given through oral incubation for 6 days prior to malathion administration. Animals from all the groups were sacrified at sampling times of 24 and 48 hours and their bone marrow cells were analyzed for chromosomal damages. The animals of the positive control group (Malathion alone) showed a significant increase in chromosomal aberrations both at 24 and 48 h sampling time. The green tea and ginger extracts, alone did not significantly induced aberrations at either sampling time, conforming their non-mutagenicity. However, significant suppressions in the chromosomal aberrations were recorded following pretreatment with green tea and ginger extracts administration. The antigenotoxic effects of both extracts separately and in mixture were also evident, as observed by significant increase in mitotic index, when compared to positive control group. Reduction in malathion induced clastogenicity by both extracts, was evident at 24 h and to a much greater extent at 48 h of cell cycle. Thus results of the present investigations revealed that green tea and ginger extracts have chemoprotective potential against malathion induced chromosomal mutations in albino mice.
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