Hydroalcoholic extract effect of Lavandula officinalis on motor functions in the male rat model of pseudo Parkinson’s disease
2017
Abrishamdar, Maryam | Moazedi, Ahmad Ali | Arzi, Ardeshir | Parham, Gholam Ali
BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder that involves approximately 1% of the population older than 50 years. Classically, PD is considered a motor system disease, and its diagnosis is based on the presence of a set of cardinal motoric signs (e.g. rigidity, bradykinesia, motor and postural reflex disturbance). ObjectiveS: The present study aimed to evaluate the effects of hydro-alcoholic extract of lavender (Lavandula officinalis) on motor disorders of pseudo PD rats. Methods: Male Wistar rats were divided into four groups (n=7). PD signs were induced by intra-peritoneal (IP) injection of reserpine (5mg/kg) prior to administration of the lavender extract. Three goups of rats received different doses (200, 300, 400 mg/kg, P.O) of the lavender extract and sham group received distilled water at the same volume for six days and two times per day. At the seventh day, Catalepsy and other signs of PD were measured in the bar test, rotarod and open field. Results: In this study, improvement in signs of Parkinson disease were not observed by applying lavender hydro-alcoholic extract and motor disorders were not reduced in comparison with sham group. Conclusions: The lavender hydro-alcoholic extract does not have any effect on motor disorders of Parkinson disease.
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