Assessing the Serum Metabolic Biomarkers of Darehshori Horses and Their Relationships With Each Other
2018
Chalmeh, Aliasghar | Pourjafar, Mehrdad | Nazifi, Saeid | Heydari, Seyed Mohammad Mahdi | Alipour, Ali | Saadat Akhtar, Iman | Nooranizadeh, Mohammad Hosein | Khoshronejad, Vahidreza
BACKGROUND: Different breeds of horses have distinct andspecific metabolic profiles which reflect the health status of horses. OBJECTIVES:The present study was performed to determine the circulating metabolicbiomarkers and their correlations in Darehshori horses. METHODS: Bloodsamples were taken from 56 Darehshori horses (5 to 7 years old). They weredivided into 2 groups containing 26 non-pregnant and non-lactating mares and 30stallions. Sera were separated and assayed for glucose, insulin,beta-hydroxybutiric acid, non-esterified fatty acid, cholesterol, triglycerideand high, low and very low density lipoproteins. RESULTS: Serum concentrationof beta-hydroxybutiric acid in stallions was significantly higher than inmares. The remaining metabolic biomarkers showed no significant differencesbetween the two studied groups. There were negative and non- significantcorrelations between insulin and glucose in both sexes. Insulin was negativelycorrelated with cholesterol, triglyceride and high, low and very low densitylipoproteins in studied groups. The negative relationships were seen amongglucose and cholesterol, triglyceride and high, low and very low densitylipoproteins in mares and stallions. In both groups, non-esterified fatty acidand beta-hydroxybutiric acid were negatively correlated with serum lipidprofile. CONCLUSIONS: The results of the present study provided ageneral pattern for normal values of metabolic profile biomarkers innon-pregnant mares and stallions of Darehshori horses. These values also helpveterinarians to diagnose metabolic abnormalities of this breed. However,season, age, management, nutritional and different physiological states mayalter the values of these biomarkers and in interpreting the changes, theseconditions should be considered
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