Survey of Changes Kindling Parameters in the Model of the Classical Electrical Kindling Following Traumatic Brain Injury
2019
Hesam, Soghra | sayyah, Mohammad | Babapour, Vahhab | Zendehdel, Morteza | Gholami Pour Badei, Hamid
BACKGROUND: Traumatic Brain Injury (TBI) is one of the prevalent medical problems. Post Traumatic Epilepsy (PTE) is one of the complications of TBI. Traumatic and ischemic brain injuries are amongst the well-known risk factors of developing PTE Objectives: The present study tends to figure out changing kindling parameters in the model of the classical electrical epilepsy following traumatic brain injury. Methods: Male Wistar rats became epileptic using the amygdala kindling model of epilepsy. Rats underwent stereotaxic surgery. Five days thereafter, trauma was exerted to the temporo-parietal cortex of the rats by Controlled Cortical Impact (CCI) device causing a 2 mm lesion. After 24 hours, kindling stimulations were started. Each stimulus is delivered at an intensity of 200-500 µA, with 50 Hz frequency with monophasic square wave train stimulations once daily. One control group with no trauma and just kindling stimulation was considered in experimental groups. A sham group was also considered in which animals underwent all procedures including surgery and kindling stimulations without trauma. Results: Mean number of 14 stimulations is needed for kindled state in control and sham groups. Traumatic rats became kindled with a significantly lower number of electrical stimulations (5 stimulations). The after discharge duration (AD) at stage 5, after discharge duration (AD) at stage 3, total duration of seizure behavior (SD) and duration of stage 5 seizure behavior (S5D) in traumatic rats were higher than threshold with control and sham group. The threshold of seizures in traumatic rats was significantly lower than the threshold in control and sham groups. Conclusions: Classical electric kindling after trauma has a significant effect on the parameters of the kindling.
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Эту запись предоставил University of Tehran
