Richness of human gut microbiome correlates with metabolic markers
2013
Le Chatelier, Emmanuelle | Nielsen, Trine | Qin, Junjie | Prifti, Edi | Hildebrand, Falk | Falony, Gwen | Almeida, Mathieu | Arumugam, Manimozhiyan | Batto, Jean-Michel | Kennedy, Sean | Léonard, Pierre | Li, Junhua | Burgdorf, Kristoffer | Grarup, Niels | Jørgensen, Torben | Brandslund, Ivan | Nielsen, Henrik Bjørn | Juncker, Agnieszka S. | Bertalan, Marcelo | Levenez, Florence | Pons, Nicolas | Rasmussen, Simon | Sunagawa, Shinichi | Tap, Julien | Tims, Sebastian | Zoetendal, Erwin G. | Brunak, Søren | Clément, Karine | Dore, Joel | Kleerebezem, Michiel | Kristiansen, Karsten | Renault, Pierre | Sicheritz-Ponten, Thomas | de Vos, Willem M. | Zucker, Jean-Daniel | Raes, Jeroen | Hansen, Torben | Bork, Peer | Wang, Jun | Ehrlich, Stanislav | Pedersen, Oluf | Guédon, Eric | Delorme, Christine | Layec, Séverine | Kaci, Ghalia | van de Guchte, Maarten | Vandemeulebrouck, Gaetana | Jamet, Alexandre | Dervyn, Rozenn | Sanchez, Nicolas | Maguin, Emmanuelle | Haimet, Florence | Winogradsky, Yohanan | Cultrone, Antonietta | Leclerc, Marion | Juste, Catherine | Blottiere, Herve | MetaGenoPolis ; Institut National de la Recherche Agronomique (INRA) | Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) ; Faculty of Health and Medical Sciences ; University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH) | Beijing Genomics Institute [Shenzhen] (BGI) | Department of Structural Biology ; Flanders Institute for Biotechnology | Department of Bioscience Engineering ; Vrije Universiteit Brussel [Bruxelles] (VUB) | School of Bioscience and Biotechnology ; Southern University of Science and Technology (SUSTech) | Research Centre for Prevention and Health (RCPH) ; Department of Public Health [Copenhagen] ; Faculty of Health and Medical Sciences ; University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Health and Medical Sciences ; University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Capital Region of Denmark | Faculty of Health and Medical Sciences ; University of Copenhagen = Københavns Universitet (UCPH) | Faculty of Medicine, Institute of Public Health ; Aalborg University [Denmark] (AAU) | Department of Clinical Biochemistry ; Vejle Hospital [Danemark] | Institute of Regional Health Research ; University of Southern Denmark (SDU) | Center for Biological Sequence Analysis & Novo Nordisk Foundation Center for Biosustainability ; Danmarks Tekniske Universitet = Technical University of Denmark (DTU) | Laboratory of Microbiology ; Wageningen University and Research [Wageningen] (WUR) | U872 Centre de Recherche des Cordeliers, Nutriomique, Équipe 7 ; Centre de Recherche des Cordeliers (CRC (UMR_S 872)) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) | Université Pierre et Marie Curie - Paris 6 (UPMC) | Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) ; Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Department of Biology [Copenhagen] ; Faculty of Science [Copenhagen] ; University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH) | Department of Bacteriology and Immunology [Helsinki] ; Haartman Institute [Helsinki] ; Faculty of Medecine [Helsinki] ; Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Medecine [Helsinki] ; Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki | Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO) ; Université Gaston Berger de Saint-Louis Sénégal (UGB)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Yaoundé I (UY1)-Institut de la francophonie pour l'informatique-Université Cadi Ayyad [Marrakech] (UCA)-Université Cheikh Anta Diop de Dakar [Sénégal] (UCAD) | Faculty of Health Sciences ; University of Southern Denmark (SDU) | King Abdulaziz University | Center for Sequencing ; Aarhus University [Aarhus] | Hagedorn Research Institute | Faculty of Health ; Aarhus University [Aarhus] | Département Microbiologie et Chaîne Alimentaire (MICA) ; Institut National de la Recherche Agronomique (INRA) | European Community (HEALTH-F4-2007-201052) - Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care (LuCamp) - ANR MicroObes, the Metagenopolis grant (ANR-11-DPBS-0001 ) - Region Ile de France (CODDIM) - Fondacoeur - Novo Nordisk Foundation | ANR-11-DPBS-0001,MGP,MetaGenoPolis(2011)
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
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