Manniindole, an indole derivative from the roots ofAnonidium manniiand combined antischistosomal and enzymatic activities
Toussi Matchi, Josette Linda | Tchamo Noungoue, Diderot | Kuhn, Isabelle | Boissier, Jerome | Tchouankeu, Jean Claude | Nothisen, Marc | Chaubet, Guilhem | Garnier, Delphine | Ursuegui, Sylvain | Ngouela, Silvere Augustin | Wagner, Alain
A new alkaloid, manniindole1, together with four known compounds: aristolactam AII2, aristolactam BII3, piperolactam D4and polycarpol5were isolated from the crude extract EtOH-H2O (8:2) of the roots ofAnonidium manniiby chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their anti-schistosomal activity againstSchistosoma mansoniand for cytotoxicity activity against Huh7 and A549 cells. Furthermore, they were also testedin vitroon the recent characterizedSchistosoma mansoniNAD(+)catabolizing enzyme (SmNACE) for their impact on this enzyme which is localized on the outer surface of the adult parasite. Compound2displayed quite good worm killing capability, while4showed significant inhibition ofSmNACE.
Показать больше [+] Меньше [-]Ключевые слова АГРОВОК
Библиографическая информация
Эту запись предоставил Ifremer
