Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE)
2017
Rios, Paula | Bailey, Helen | Lacour, Brigitte | Valteau-Couanet, Dominique | Michon, Jean | Bergeron, Christophe | Boutroux, Hélène | Defachelles, Anne-Sophie | Gambart, Marion | Sirvent, Nicolas | Thebaud, Estelle | Ducassou, Stéphane | Orsi, Laurent | Clavel, Jacqueline | Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153) ; Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Registre National des Tumeurs Solides de l'Enfant (RNTSE) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) | Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy] (RNCE) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy] ; Institut Gustave Roussy (IGR) | Société française de lutte contre les cancers et les leucémies de l’enfant et de l’adolescent (SFCE) | Service d'Oncologie ; Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe) ; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) | Centre de Recherche Saint-Antoine (UMRS893) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | MYPAC ; Université Pierre et Marie Curie - Paris 6 (UPMC) | CHU Trousseau [APHP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) | Centre Oscar Lambert | Service Anatomie et cytologie pathologiques [CHU Toulouse] ; Pôle Biologie [CHU Toulouse] ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) | Département d'Oncologie Pédiatrique [CHU Nantes] ; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) | CHU de Bordeaux Pellegrin [Bordeaux] | Registre National des Hémopathies malignes de l'Enfant (RNHE) ; Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
International audience
Показать больше [+] Меньше [-]Английский. Purpose: Neuroblastoma (NB) is an embryonic tumor that occurs almost exclusively in infancy and early childhood. While considerable evidence suggests that it may be initiated during embryonic development, the etiology of NB is still unknown. The aim of this study was to explore whether there is an association between maternal use of household pesticides during pregnancy and the risk of NB in the offspring.Methods: We conducted a pooled analysis of two French national-based case-control studies. The mothers of 357 NB cases and 1,783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on sociodemographic and perinatal characteristics, childhood environment, and life-style. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals.Results: After controlling for matching variables, study of origin, and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with NB (OR 1.5 [95% CI 1.2-1.9]). The most commonly used type of pesticides were insecticides and there was a positive association with their use alone (OR 1.4 [95% CI 1.1-1.9]) or with other pesticides (OR 2.0 [95% CI 1.1-3.4]).Conclusions: Although there is the potential for recall bias due to the study design, our findings add to the evidence of an association between the household use of pesticides and NB. Until a better study design can be found, our findings add yet another reason why to advise pregnant women to limit pesticide exposure during the periconceptional period.
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Эту запись предоставил Institut national de la recherche agronomique
