In Vivo Anti-Inflammatory Effect of a New Steroidal Saponin, Mannioside A, and Its Derivatives Isolated from Dracaena mannii
2008
Gomez-Cadenas, Aurelio | Azefack Tapondjou, Leon | Beaudelaire Ponou, Kemvoufo | Bertrand Teponno, Remy | Mbiantcha, Marius | Djoukeng, Jules Désiré | Benoit Nguelefack, Télesphore | Watcho, Pierre | Park, Hee-Juhn
A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-β-D-glucopyranoside (3) and pennogenin-3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.
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