Antimicrobial and cytotoxic extractives from <i>Ficus sycomorus</i> L. (Moraceae)
2022
Vanini Samiyatou Michiren Mandou | Willifred Dongmo Tekapi Tsopgni | Mohamed Foundikou Nsangou | Gervais Mouthe Happi | Alain François Kamdem Waffo | Emmanuel Ngeufa Happi
Our search for antimicrobial and cytotoxic leads from <i>Ficus sycomorus</i> led to the isolation of twenty-four known compounds (<b>1</b>‒<b>24</b>) from its methanolic stem bark and root extracts. The structures of all the isolated compounds were established using their 1D- and 2D-NMR spectroscopic data while the crude extracts, some fractions and compounds were tested for their antibacterial, antifungal and cytotoxicity activities. In the antimicrobial assay, compound <b>18</b> displayed good to moderate activity with MIC values of 31.25 µg/ml against <i>Escherichia coli</i>, 125 µg/ml against <i>Salmonella typhimurium</i> cpc and <i>Pseudomonas aeruginosa</i>, while compounds <b>10</b>, <b>13</b> and <b>14</b> demonstrated moderate activities on almost all the tested strains, with the highest potency observed for compound <b>13</b> on <i>E. coli</i> (MIC = 125 µg/ml). However, although compounds <b>18</b> and <b>19</b> gave a significant inhibition of the VERO cell line ATCC CRT-1586 with CC<sub>50</sub> values of 52.60 µg/ml and 69.10 µg/ml, respectively, all the extract samples and other tested compounds did not show distinguishable cytotoxicity. Finally, the chemophenetic significance of the isolated compounds is discussed.
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