Diverse Functions of Multiple <i>Bdnf</i> Transcripts Driven by Distinct <i>Bdnf</i> Promoters
2023
He You | Bai Lu
The gene encoding brain-derived neurotrophic factor (<i>Bdnf</i>) consists of nine non-coding exons driven by unique promoters, leading to the expression of nine <i>Bdnf</i> transcripts that play different roles in various brain regions and physiological stages. In this manuscript, we present a comprehensive overview of the molecular regulation and structural characteristics of the multiple <i>Bdnf</i> promoters, along with a summary of the current knowledge on the cellular and physiological functions of the distinct <i>Bdnf</i> transcripts produced by these promoters. Specifically, we summarized the role of <i>Bdnf</i> transcripts in psychiatric disorders, including schizophrenia and anxiety, as well as the cognitive functions associated with specific <i>Bdnf</i> promoters. Moreover, we examine the involvement of different <i>Bdnf</i> promoters in various aspects of metabolism. Finally, we propose future research directions that will enhance our understanding of the complex functions of <i>Bdnf</i> and its diverse promoters.
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