Mutational and phylogenetic status of west siberian strains of BLV
Blazhko Natalia | Shatokhin Kirill | Khripko Yuriy | Ngirande Charity | Kochnev Nikolai
The study is devoted of full-genome BLV sequences circulating in cattle populations of the Novosibirsk region, Russia. The phylogenetic tree shows that the West Siberian isolates are quite closely related to such previously isolated strains as AF399704 (Brazil), AP018007, AP018016, AP018019, LC007988, LC007991 (Japan) and EF065638 (Belgium) we calculations show that the number of mutations that could independently occur in parallel evolving BLV strains significantly exceeds the expected number based on the probability of corresponding substitutions. It was also found that the studied isolates have some mutations, the presence of which, at first glance, is possible only with their divergent development in different independently evolving branches. However, calculations show that the probability of an independent origin of an identical mutation is extremely small, which indicates the possibility of exchanging RNA sites between isolates circulating in West Siberian cattle populations.
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