EFFECT OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) IN COMPARISON WITH BASIS STRUCTURAL COMPOUNDS ON SOME PROTEIC METABOLISM PARAMETERS IN RATS

LETIŢIA STANA; ALEXANDRA TRIF; LOREDANA GABRIELA STANA; ALFA XENIA LUPEA; MIRABELA PĂDURE; F. MUSELIN

EFFECT OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) IN COMPARISON WITH BASIS STRUCTURAL COMPOUNDS ON SOME PROTEIC METABOLISM PARAMETERS IN RATS

2023

The aim of the study was to relieve the effect of synthesis product (by-product of salicylic acid) administration 5-cloro-2hidroxy-azotil-sulfamoil-fenil benzamide (5ClSA-SA) in comparison with basic structural compounds (salicylamide and sulfanilamide) on some parameters of proteic metabolism on rats. The synthesis product 5ClSA-SA is amide of 5 chlorosalycilic acid with sulfanilamide synthesized at The Technical University, Faculty of Industrial Chemistry of Timisoara. The experimental results demonstrate that the synthesis product has determinate a strong significant increase (p<0.01) of proteinemia compared to test, over the physiological limits; salicylamide has induces the significant increase (p<0.05), and sulfanilamide has induced the significant decrease (p<0.05) of total proteins compared to test but in physiological limits. After the administration of the three substances, the albumin and urea values has strong significant decrease (p<0.01) compared to test and under the physiological limits. The synthesis product has not determinate significant differences (p>0.05) of creatinine compared to test, obtained values being situated in physiological limits, while salicylamide and sulfanilamide have induced strong significant decrease (p>0.01), respectively significant (p>0.05) compared to test and under physiological limits.

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