Cembranoids from Octocoral <i>Lobophytum crassum</i> (von Marenzeller, 1886)
Yao-Tsung Yeh | Sung-Chun Lin | Gene-Hsiang Lee | Zhi-Hong Wen | Tsong-Long Hwang | Yu-Jen Wu | Jih-Jung Chen | Lee-Shing Fang | Mei-Kang Yuan | Ping-Jyun Sung
Two cembranoids, including a new compound, lobocrassin I (<b>1</b>), as well as a known analogue, lobohedleolide (<b>2</b>), were obtained by solvent extraction from octocoral <i>Lobophytum crassum</i>. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid <b>2</b> exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.
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