Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
2022
Anouk M. La Rose | Anouk G. Groenen | Benedek Halmos | Venetia Bazioti | Martijn G.S. Rutten | Kishore A. Krishnamurthy | Mirjam H. Koster | Niels J. Kloosterhuis | Marieke Smit | Rick Havinga | Gilles Mithieux | Fabienne Rajas | Folkert Kuipers | Maaike H. Oosterveer | Marit Westerterp
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
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