Anti-Aging Potential of Extracts from <i>Washingtonia filifera</i> Seeds
Benedetta Era | Sonia Floris | Valeria Sogos | Clara Porcedda | Alessandra Piras | Rosaria Medda | Antonella Fais | Francesca Pintus
The aim of this study was to test the inhibitory effect of fruit extracts from <i>Washingtonia filifera</i> on skin aging-related enzymes. The pulp extracts did not exert a significant enzyme inhibition while seed extracts from <i>W. filifera</i> exhibit anti-elastase, anti-collagenase, and anti-tyrosinase activities. Tyrosinase was mildly inhibited while a stronger effect was observed with respect to elastase and collagenase inhibition. Alcoholic extracts provided better results than aqueous extracts. Among them, methanol extracts showed the prominent enzyme inhibitory activities being IC<sub>50</sub> value for elastase and collagenase comparable and even better than the reference compound. The inhibition mode of the most active extracts was investigated by Lineweaver-Burk plot analysis. Seed extracts from <i>W. filifera</i> were also investigated for their photo-protective effect by Mansur equation and the antioxidant activity of <i>W. filifera</i> extract was evaluated in oxidative-stressed cells. To evaluate the safety of the extract, the effect on cell viability of human keratinocytes cells was analyzed. Methanol extract presented the best photo-protective effect and exerted an antioxidant activity in a cellular system with no cytotoxic effect. The overall results demonstrate that <i>W. filifera</i> extracts are promising sources of bioactive compounds that could be used in cosmetic and pharmaceutical preparation.
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