Research progress on the determination of free-base nicotine in tobacco and tobacco products
2022
ZHANG Hao | HAN Shu-lei | CHEN Huan | HOU Hong-wei | HU Qing-yuan
The research progress on determination of free-base nicotine in tobacco and tobacco products in the past 30 years was reviewed and discussed, including solvent extraction method, headspace solid-phase microextraction method, <sup>1</sup>H NMR, Henderson-Hasselbalch method and spectroscopy method, etc. Advantages and limitations of each method were summarized and discussed and the development in this field was prospected.
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