Genome-Wide Screening and Characterization of Methyl-CpG-Binding Domain (MBD) Proteins in <i>Arabidopsis</i> Species
2024
Hong-Hui Cui | Man-Man Sun | Xiao-Juan Huang | Hong-Ze Liao
Methyl-CpG-binding domain (MBD) proteins play vital roles in epigenetic gene regulation, and they have diverse molecular, cellular, and biological functions in plants. MBD proteins have been functionally characterized in a few plant species. However, the structure and function of MBD proteins in <i>Arabidopsis halleri</i> and <i>Arabidopsis lyrata</i> remain unknown. In this study, 12 <i>A. halleri</i> MBD (AhMBD) and 13 <i>A. lyrata</i> MBD (AlMBD) genes were identified. A phylogenetic analysis of the <i>Arabidopsis</i> genus showed that the MBD proteins of three species (<i>Arabidopsis thaliana</i>, <i>A. helleri</i>, and <i>A. lyrata</i>) could be classified into eight classes. Expression patterns suggested that the <i>AtMBD</i> genes were expressed in different tissues. We characterized the function of <i>AtMBD3</i> and found that it was constitutively localized to the nucleus and interacted with several AtMBD protein members. Our results reveal that <i>AtMBD3</i> is involved in the development of <i>A. thaliana</i>, which may be helpful in further studies on these genes in <i>A. helleri</i> and <i>A. lyrata</i>.
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