Evaluation of the effectiveness of the feed supplement “Hepatoprotect” in acute toxic hepatitis of rabbits
2023
Dombrovsky, Vladislav O. | Matrosova, Lilia E. | Sagdeev, Danil R. | Sagdeeva, Zukhra Kh.
Introduction. The liver is an important organ for animals and humans, most often playing a key role in the conversion and excretion of xenobiotics. Some medicinal substances entering the body at or exceeding the therapeutic dose, as well as natural and man-made ecotoxicants, lead to various liver pathologies. The development of drugs that improve metabolic processes in the liver and increase its resistance to pathogenic effects is an urgent direction. The aim is to evaluate the effectiveness of the new complex supplement “Hepatoprotect” in acute toxic hepatitis in rabbits. Materials and methods. 24 rabbits (n=6) were used in the experiments. Rabbits of the first group served as biological control. Acute hepatitis was caused by intraperitoneal administration of 50 % carbon tetrachloride solution (solvent olive oil) in a volume of 1 ml/kg to animals of the second, third and fourth groups. The animals of the third group were intragastrically given the commercial drug “Karsil” (100 mg/kg of body weight), the fourth with the feed feed additive “Hepatoprotect” (25 g/kg of feed). The drugs were given once for 14 days. The results of the research. The research results indicate the hepatoprotective effect of the developed feed additive “Hepatoprotect”. The protective effect of the studied agent was manifested in a decrease in hepatotoxicity caused by the introduction of carbon tetrachloride.
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