Modeling properties of chromosome territories using polymer filaments in diverse confinement geometries

Nahali, Negar; Oshaghi, Mohammadsaleh; Paulsen, Jonas

Modeling properties of chromosome territories using polymer filaments in diverse confinement geometries | ENEngelskEnglishModeling properties of chromosome territories using polymer filaments in diverse confinement geometries

2024

Nahali, Negar | Oshaghi, Mohammadsaleh | Paulsen, Jonas

Interphase chromosomes reside within distinct nuclear regions known as chromosome territories (CTs). Recent observations from Hi-C analyses, a method mapping chromosomal interactions, have revealed varied decay in contact probabilities among different chromosomes. Our study explores the relationship between this contact decay and the particular shapes of the chromosome territories they occupy. For this, we employed molecular dynamics (MD) simulations to examine how confined polymers, resembling chromosomes, behave within different confinement geometries similar to chromosome territory boundaries. Our simulations unveil so far unreported relationships between contact probabilities and end-to-end distances varying based on different confinement geometries. These findings highlight the crucial impact of chromosome territories on shaping the larger-scale properties of 3D genome organization. They emphasize the intrinsic connection between the shapes of these territories and the contact behaviors exhibited by chromosomes. Understanding these correlations is key to accurately interpret Hi-C and microscopy data, and offers vital insights into the foundational principles governing genomic organization.

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