Triphenyltin alters lipid homeostasis in females of the ramshorn snail Marisa cornuarietis
Lyssimachou, Angeliki | Navarro, Juan Carlos | Bachmann, Jean | Porte Visa, Cinta
29 p., 3 tablas, 2 figuras y bibliografía
Показать больше [+] Меньше [-]Molluscs are sensitive species to the toxic effects of organotin compounds, particularly to masculinization, and both, tributyltin (TBT) and triphenyltin (TPT) have been recently shown to bind to molluscs RXR. Being RXR is involved in lipid homeostasis, exposure to TPT would have an immediate effect on lipid homeostasis. To test this hypothesis, the ramshorn snail Marisa cornuarietis was exposed to environmentally relevant concentrations of TPT (30, 125, 500 ng/L as Sn) in a semi-static water regime for 7-days. Percentage of lipids and total fatty acid content decreased significantly in TPT-exposed females while the activity of peroxisomal acyl-CoA oxidase, involved in fatty acid catabolism, increased. In addition, fatty acid profiles (carbon chain length and unsaturation degree) were significantly altered in exposed females but not in males. This work highlights the ability of TPT to disrupt lipid metabolism in M. cornuarietis at environmentally realistic concentrations and the higher susceptibility of females in comparison to males.
Показать больше [+] Меньше [-]This study was supported by the European Union (COMPRENDO-Project, EVK1-CT-2002-00129) and the Spanish National Plan for Research (Project Ref CGL2005-02846).
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