Potentiation of Toxicology with Proteomics: Toxicoproteomics
2022
Yipel, Mustafa | İlhan, Aysun
Proteomics, which is called the identification phase of the proteome identifying all the proteins encoded by the genome, has an important place in solving the difficulties experienced in toxicology. Proteomics refers to the study of interactions with other proteins and macromolecules, structure, location, amount, post-translational modifications (PTM), function in tissues/cells of the proteome. With proteomic studies, new relationships between proteins and toxicopathological effects can be determined and it is revealed the information on the toxic action mechanisms of various substances, from metals to peroxisome proliferators. On the other hand, toxicoproteomics seeks to identify critical proteins and pathways in biological systems that respond to it and adversely affected by chemical and environmental exposures using protein expression technologies. Toxicoproteomics combines 3 discipline areas. These are 1) traditional toxicology and pathology 2) differential protein and gene expression analysis 3) systems biology. Toxicoproteomic studies are an important area that can provide critical tools for identification of biomarkers associated with exposure to toxic substances, assessing their reliability and designing appropriate measures that can minimize adverse effects. In this statement, it is aimed to emphasize the importance of proteomics in toxicology.
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